5 points (A) and net worsening of 2.5 points or more (B). Results: Before the second TACE, 43 patients (31%) had a score ART ≥2.5 and 96 patients a score ART between 0 and 1.5. The median overall survival of our population was 28 months (22,

34). There was a significant difference between the two groups A and B regarding median survival (p < 0.0001), with a median of 34 months A (28–38) and 13 months B (10–16). There was a significant difference between the two groups regarding the value of AFP, Child-Pugh score, BCLC classification, encapsulated character or infiltrating tumor, the presence of a segmental portal vein thrombosis. There was a significant difference in response rate after TACE and with median time to progression. But there was no difference between the two groups regarding patient age, BMI, underlying liver disease, the presence of diabetes, the circumstances of discovery, the presence of Lapatinib cell line significant Esophageal varices, the existence of a previous treatment. Conclusion: This study confirms the prognostic value of ART score calculated before the second TACE in a different population, in better condition with more often viral disease. Elevated transaminases frequently observed in viral diseases do not interfere on the reliability of the score. Key Word(s): 1. chemoembolization; 2. HCC; 3. BCLC classification; 4. ART score; Presenting Author: ADHOUTE XAVIER Additional Authors: CASTELLANI PAUL, POL BERNARD,

PERRIER HERVÉ, CAMPANILE MANUELA, WENDT ASTRID, BEAURAIN PATRICK, MONNET OLIVIER, PENARANDA GUILLAUME, RAOUL JEAN LUC, BOURLIERE MARC Corresponding Author: ADHOUTE XAVIER Affiliations: Fondation Saint-Joseph; Alphabio Laboratory; see more Institut Paoli Calmettes Objective: Primary liver cancers are dominated by hepatocellular carcinoma (HCC), which mainly develops on chronic liver disease (HBV,

HCV, alcohol, metabolic syndrome). Intrahepatic cholangiocarcinoma medchemexpress (ICC) are the second most common primary liver malignancy, they arise from bile duct epithelium within the liver. Their incidence is increasing in the West, Oceania, United States. Besides the classical etiologies (intrahepatic cholelithiasis, cholangitis, parasitosis), new risk factors are suspected: cirrhosis, chronic hepatitis (HCV, HBV), metabolic syndrome, type II diabetes. Aim of the study: risk factors associated with Intrahepatic cholangiocarcinoma. Presentation, course and treatments. Comparative study with HCC. Methods: Material and method: During the period 01/2007 – 12/2012, 405 consecutive patients were admitted to our unit for the management of Primary liver tumors. HCC diagnosis was based on EASL criteria. Patients without cirrhosis had tumor biopsy. Etiology of liver disease was systematically sought: HBV, HCV, iron load, auto-immune markers and metabolic syndrome. Results: The diagnosis of ICC was based on histology in 100% of cases vs 18% for HCC (EASL radiological criteria) (p < .0001). ICC accounted for 8% (n = 32) of the pts.