Response to milk free diet Results: N = 26, M: F – 14:12. Median age: 16.88 months (SD +/− 10.27). Mean duration between presentation and introduction of cow milk: 8.18 months (0.5–29). Presentation: 15 (57.6%) – chronic diarrhea and blood in stool, 10 (38.4%) – chronic diarrhea and failure to thrive. Endoscopic rectal mucosal biopsies were performed in 20 (76.9%) and EGD with duodenal

biopsies in 6 (23%) – all were positive. Mean follow up: 7.23 PLX4032 molecular weight months (SD +/− 5.49). All patients responded to milk free diet. Peptide based chicken formula prescribed in 9 (34.6%) and extensively hydrolyzed amino acid formula given to 3 (11.5%). Remaining 14 (53%) were managed on home made diet. Re-challenge was undertaken in 7 after parental consent. Re – challenge was done at 2 years of age or one year after stopping milk. Only one patient presented with recurrence following re-challenge. Conclusion: Chronic diarrhea, blood in stool and failure to thrive are common presenting symptoms of CMPA. Mucosal biopsies help in establishing diagnosis. More than 50% patients can be managed with a home-modified diet. Key Word(s): 1. cow milk protein allergy;

2. milk protein allergy; 3. paediatric diarrhoea Presenting Author: ERIC CHEAH Additional Authors: KEVIN GASKIN, MICHAEL STORMON, SHOMA DUTT, ANNABEL MAGOFFIN, EDWARD O’LOUGHLIN Corresponding Author: ERIC CHEAH Affiliations: EPZ-6438 chemical structure The Children’s Hospital at Westmead, The Children’s this website Hospital at Westmead, The Children’s Hospital at Westmead, The Children’s Hospital at Westmead, The Children’s Hospital at Westmead

Objective: Eosinophilic oesophagitis (EO) is a chronic, immune/antigen-mediated oesophageal disease characterized by oesophageal dysfunction and histologically by eosinophil-predominant inflammation. This study will report on our 5 year experience in children diagnosed with EO at the Children’s Hospital at Westmead, a tertiary paediatric institution in Sydney, Australia. Methods: A retrospective audit was performed between January 1, 2008 and December 31, 2012 to evaluate all patients newly diagnosed with EO. The follow up period was included up to May 31, 2014. Demographic data, clinical symptoms, associated conditions, atopic history and treatment modalities were collated. Results: A total of 108 patients were diagnosed with EO: 71% male, median age 6.8 years (range 0.8–16.8 years); representing an average of 4% of total endoscopies performed per year. 41 patients had dysphagia symptoms, 34 patients had gastro-oesophageal reflux symptoms, 11 patients with abdominal pain and 23 patients with non-EO symptoms. Atopic history was elicited in 54% of patients whilst 36% had food allergy. Concomitant diagnosis included coeliac disease, Helicobacter pylori gastritis and proctitis/ulcerative colitis. Endoscopic appearance was normal in 8.3% of patients. Patients required a median of 2 (range 0–10) follow up endoscopies. Treatments are presented in Table 1.