Subsequent intake of a tocotrienol-free diet with or without alpha-tocopherol for 7 days depleted concentrations of alpha- and gamma-tocotrienol in serum and tissues, which was accompanied by a decrease in the excretion of gamma-tocotrienol metabolite. However, neither the tocotrienol concentration nor gamma-tocotrienol metabolite excretion was affected by dietary alpha-tocopherol. These data showed that dietary find more alpha-tocopherol did not accelerate the depletion of gamma-tocopherol and tocotrienol

and their metabolite excretions, suggesting that the positive effect of alpha-tocopherol on vitamin E omega-hydroxylase is not sufficient to affect the other isoform concentrations in tissues.”
“Several immune functions are markers of health, biological age and predictors of longevity. A chronic oxidative and inflammatory state is the main cause of ageing and the immune system is involved in the rate of ageing. Thus, several murine models of premature ageing have been proposed owing to their early immunosenescence

and oxidative stress, such as ovariectomised rats and mice, obese rats and anxious mice. In the last model, the most extensively studied by us, mice showing anxiety have an aged immune function and redox status as well Nirogacestat mouse as a shorter longevity in comparison with animals without anxiety of the same chronological age, being denominated prematurely ageing mice. A confirmation of the above is that the administration of diets supplemented with antioxidants improves the redox status and immune functions and increases the longevity of prematurely ageing mice. Antioxidant precursors of glutathione such as thioproline or N-acetylcysteine, which have a relevant role in ageing, have been the most widely investigated in adult prematurely ageing mice in our laboratory. In the present work, we have studied the effects of the ingestion for 5 weeks of a diet supplemented with 0.1% (w/w) thioproline + N-acetylcysteine on several functions of GPCR Compound Library purchase leucocytes from chronological old (69-73

weeks of age) prematurely ageing mice of two strains (Swiss and BALB/c). The results show an improvement of the immune functions, with their values becoming closer to those in adult animals (24 +/- 2 weeks). Thus, an adequate nutrition with antioxidants, even in aged subjects, could be a good strategy to retard ageing.”
“Matrix metalloproteinase 9 (MMP-9) has been implicated in airway injury in chronic obstructive pulmonary disease (COPD), lung inflammation, and lung cancer and plays a major role in tumor necrosis factor-alpha (TNF-alpha)-stimulated tumor invasion and lung inflammation. MMP-9 activity is promoted by the pro-inflammatory cytokine TNF-alpha. GMI, cloned from Ganoderma microsporum and purified, is one of the recombinant fungal immunomodulatory proteins.