014), hepatitis A virus antibodies (56% vs 90%; p=0.046), coronary artery disease (15% vs 45%; p=0.03) and cirrhosis (38%

vs 73%; p= 0.047). Overall, 40 (42%) patients had cirrhosis. When compared to non-cirrhotics, more cirrhotic patients were male (63% vs 83%; p= 0.04), had liver steatosis (27% vs 55%; p= 0.006) and +HEV-IgG (5% vs 20%; p= 0.047). There were no differences between cirrhotic and non-cirrhotic groups regarding years of HCV infection, history of alcohol consumption, type of cancer, chemotherapy, HCV treatment history, and HIV or HBV co-infection. In multivariate analysis, the only factors independently associated with cirrhosis were liver steatosis (OR= 3.4; 95% CI 1.4-8.2; p= 0.007] and +HEV-IgG (OR= 4.5; 95% CI 1.119.3; p= 0.04). Conclusions: HEV seropositivity is high (12%) in HCV-infected FDA-approved Drug Library price cancer patients living in the US and is significantly associated Autophagy inhibitor with cirrhosis in this population. The role of HEV infection (diagnosed by HEV-RNA levels) in liver disease progression of

chronically infected patients with HCV requires further research. Disclosures: Harrys A. Torres – Advisory Committees or Review Panels: Merck, Vertex, Novartis, Astellas, Pfizer, Genentech, Gilead; Grant/Research Support: Merck, Vertex The following people have nothing to disclose: Andreas Kyvernitakis, Parag Mahale, Jiang Ying Background & Aim Recently, an epidemic of acute hepatitis C (AHC) among HIV-positive patients has been reported, which was attributed to a substantially 上海皓元 increased incidence among men who have sex with men. Although dual-therapy with pegylated interferon and ribavirin (PEGIFN/RBV) for up to 48 weeks is recommended by the European AIDS Treatment Network (NEAT) consensus for the treatment of AHC in this special population, sustained virologic response (SVR) rates observed in previous studies (60-80%) were unsatisfactory. We aimed to optimize SVR rates in genotype 1 AHC/HIV-coinfected patients

(HIV/AHC-GT1) by adding boceprevir (BOC) in patients without complete early virologic response (cEVR). Patients & Methods Seventeen consecutive HIV/AHC-GT1 were included in this retrospective case series. As recommended by the NEAT consensus, patients were treated with PEGIFN-α-RNA at treatment week 12), BOC was added at treatment week 12, resulting in 36 weeks of BOC/PEGIFN/RBV triple therapy (total treatment duration: 48 weeks). SVR was defined as TND HCV-RNA 24 weeks after the end of treatment. Results The majority of HIV/AHC-GT1 were infected with subtype 1a (82%), while 18% of patients had subtype 1b. One patient (6%) had liver cirrhosis of alcoholic etiology. The distribution of the interleukin 28B rs12979860 SNP genotype was: C/C:18%, C/T:65% and T/T:6%. Except for one patient (6%), all patients were on combined antiretroviral therapy (cART) with a mean CD4+ T-lymphocyte (CD4+) count of 653±205 cells/μL. Fifty-nine percent (10/17) of patients had a RVR. Four patients (24%) did not achieve a cEVR.