09-B1-021), the Scientific Research Foundation of Jiangsu Province Health Department (No. VX-680 cost H200710) and the Medical Science Development Subject in Science and Technology Project of Nanjing (No. ZKX08017 and YKK08091). References 1. Eaton KD, Martins RG: Maintenance chemotherapy in non-small cell lung cancer. J Natl Compr Canc Netw 2010, 8: 815–821.PubMed 2. Kostova I: Platinum complexes as anticancer agents. Recent Pat.
Anticancer Drug Discov 2006, 1: 1–22.CrossRef 3. Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120: 15–20.PubMedCrossRef 4. Edwards JK, Pasqualini R, Arap W, Calin GA: MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseases. J Cardiovasc Transl Re 2010, 3: 271–279.CrossRef TSA HDAC 5. Fabbri M: miRNAs as molecular biomarkers of cancer. Expert Rev Mol Diagn 2010, 10: 435–444.PubMedCrossRef 6. Jackson A, Linsley PS: The therapeutic potential of microRNA modulation. Discov Med 2010, 9: 311–318.PubMed 7. Ma J, Dong C, Ji C: MicroRNA and drug resistance. Selleckchem NSC23766 Cancer Gene Ther 2010, 17: 523–531.PubMedCrossRef 8. Yu ZW, Zhong LP, Ji T, Zhang P, Chen WT, Zhang CP: MicroRNAs contribute to the chemoresistance of cisplatin
in tongue squamous cell carcinoma lines. Oral Oncol 2010, 46: 317–322.PubMedCrossRef 9. Sorrentino A, Liu CG, Addario A, Peschle C, Scambia G, Ferlini C: Role of microRNAs in drug-resistant ovarian cancer cells. Gynecol Oncol 2008, 11: 478–486.CrossRef 10. Masaki S, Ohtsuka R, Abe Y, Muta K, Umemura T: Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis. Biochem Biophys Res Commun 2007, 364: 509–514.PubMedCrossRef 11. Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ: miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood 2009, 113: 1794–1804.PubMedCrossRef 12. Patrick DM, Zhang
CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN: Defective erythroid differentiation in miR-451 mutant mice mediated by 14–3-3 zeta. Genes Dev the 2010, 24: 1614–1619.PubMedCrossRef 13. Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM: Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol 2008, 76: 582–588.PubMedCrossRef 14. Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther 2008, 7: 2152–2159.PubMedCrossRef 15. Amaral JD, Xavier JM, Steer CJ, Rodrigues CM: Targeting the p53 pathway of apoptosis. Curr Pharm Des 2010, 16: 2493–2503.PubMedCrossRef 16. Dykxhoorn DM: MicroRNAs and metastasis: little RNAs go a long way. Cancer Res 2010, 70: 6401–6406.PubMedCrossRef 17. Zimmerman AL, Wu S: MicroRNAs, cancer and cancer stem cells.