[10,11] These slight differences could be explained by the analytical method that was used.[11,12] On the other hand, the fact that no significant sequence effect was observed in either the fasting or the fed treatment period of the study indicates that the washout period was appropriate and {Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|buy Anti-infection Compound Library|Anti-infection Compound Library ic50|Anti-infection Compound Library price|Anti-infection Compound Library cost|Anti-infection Compound Library solubility dmso|Anti-infection Compound Library purchase|Anti-infection Compound Library manufacturer|Anti-infection Compound Library research buy|Anti-infection Compound Library order|Anti-infection Compound Library mouse|Anti-infection Compound Library chemical structure|Anti-infection Compound Library mw|Anti-infection Compound Library molecular weight|Anti-infection Compound Library datasheet|Anti-infection Compound Library supplier|Anti-infection Compound Library in vitro|Anti-infection Compound Library cell line|Anti-infection Compound Library concentration|Anti-infection Compound Library nmr|Anti-infection Compound Library in vivo|Anti-infection Compound Library clinical trial|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|buy Antiinfection Compound Library|Antiinfection Compound Library ic50|Antiinfection Compound Library price|Antiinfection Compound Library cost|Antiinfection Compound Library solubility dmso|Antiinfection Compound Library purchase|Antiinfection Compound Library manufacturer|Antiinfection Compound Library research buy|Antiinfection Compound Library order|Antiinfection Compound Library chemical structure|Antiinfection Compound Library datasheet|Antiinfection Compound Library supplier|Antiinfection Compound Library in vitro|Antiinfection Compound Library cell line|Antiinfection Compound Library concentration|Antiinfection Compound Library clinical trial|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening| that no carryover effect was present. The effect of sex was

studied as a descriptive analysis. No statistically significant differences in the pharmacokinetic parameters between male and female Selleck NVP-BSK805 subjects were observed in either the fasting or the fed states. It should be noted that female subjects had a longer tmax in the fed state than in the fasting state. Doxylamine succinate is available as an over-the-counter hypnotic agent and in many cough and cold formulations. The healthy subjects included in this study were young (between 20 and 53 years old). The absorption, distribution, metabolism, and excretion of doxylamine did not seem to be significantly affected by the age or by the sex of the subjects, although the clearance of doxylamine could be reduced in elderly men but not in elderly women.[8,9] In a post hoc analysis, no sex effect was observed. The results obtained

in this study could be extrapolated to the general population, although studies in an elderly population would be necessary. Overall, the doxylamine hydrogen succinate TCL 25 mg film-coated tablet was generally

safe and well learn more tolerated by the subjects in this study. It should be noted that most of the subjects experienced somnolence under both fasting and fed conditions when administered doxylamine hydrogen succinate 25 mg, although somnolence and sleep induction seemed to be more frequent under fed conditions. Certain aspects of the study design should be considered before drawing conclusions for future users of doxylamine hydrogen succinate, as the open-label, single-dose design and the fact that the study population consisted of healthy subjects could lead to underestimation or overestimation of the generalizability of the results beyond the population and conditions that were studied. Conclusion The usual criteria used to assess the food effect of the test formulation were fulfilled. The fed : fasting ratio of the geometric LS means and the corresponding 90% confidence intervals for Cmax and AUCt were within the range of 80–125%. Doxylamine hydrogen succinate 25 mg film-coated tablets are judged to be bioequivalent under fed and fasting conditions. Consequently, high-fat, high-calorie food intake does not affect the kinetics of doxylamine in healthy subjects. Acknowledgments Sebastián Videla and Mounia Lahjou contributed equally to this study.