62 ± 14.02  Dry weight (kg) 12 PLX4032 in vitro months, mean ± SD 66.23 ± 14.50  Interdialytic weight gain (kg) 0 months, mean ± SD 1.74 ± 1.18  Interdialytic weight gain (kg) 12 months, mean ± SD 1.54 ± 0.77 Dibutyryl-cAMP nmr Echocardiography The echocardiographic measurements for the study population are

listed in Table 2. There was a significant reduction in interventricular septal (IVS) thickness (11 ± 1 to 9 ± 2 mm, p < 0.05) as well as in posterior wall thickness (PWT), (from 12 ± 1 to 9 ± 1 mm, p < 0.05) by TTE over the one-year follow-up. In addition, there was a 15 % reduction in left ventricular mass index (LVMI, 152 ± 7 to 129 ± 8 g/m2, p < 0.05; Fig. 1) on long-term NHD. There were significant reductions in

both left atrial volume index (LAVI, 41 ± 5 to 34 ± 4 ml/m2, p < 0.05) and right atrial volume index (RAVI, 39 ± 5 to 31 ± 4 ml/m2, p < 0.05). Finally, diastolic dysfunction improved from a baseline grade of 3.4 to 1.2 after one-year follow-up (p < 0.05) as shown in Table 3. There was a decrease in the E wave velocity with no change in the A wave velocity over time, resulting in a decrease in the E/A ratio mTOR inhibitor over 1-year follow-up. The LV filling pressures, as reflected by the E/E’, also improved over time. There Alanine-glyoxylate transaminase were no significant changes in left ventricular end-systolic and end-diastolic dimensions, nor any change in left ventricular ejection fraction (LVEF) or cardiac output (CO) at one-year follow-up. There was good intra-observer

and inter-observer variability for the measurement of LVMI (Table 4). Table 2 Cardiac chamber parameters by TTE and CMR at baseline and 1-year follow-up in total population (n = 11)   TTE CMR Baseline 1 year follow-up p Baseline 1 year follow-up p LV parameters  LVEDD (mm) 45 ± 4 46 ± 4 0.86 46 ± 1 47 ± 2 0.82  LVESD (mm) 31 ± 2 32 ± 3 0.83 31 ± 3 32 ± 3 0.71  LVEDV (mL) 96 ± 9 98 ± 10 0.85 99 ± 6 100 ± 7 0.82  LVESV (mL) 29 ± 7 30 ± 6 0.77 30 ± 5 32 ± 5 0.81 IVS (mm) 11 ± 1 9 ± 2 <0.05 12 ± 1 9 ± 1 <0.05 PWT (mm) 12 ± 1 9 ± 1 <0.05 12 ± 1 9 ± 1 <0.05 SV (mL) 63 ± 11 65 ± 7 0.68 64 ± 6 66 ± 8 0.76 HR (bpm) 70 ± 7 74 ± 9 0.62 73 ± 8 75 ± 6 0.82 CO (L/min) 4.2 ± 0.9 4.6 ± 0.7 0.54 4.4 ± 0.2 4.5 ± 0.4 0.81 LVEF (%) 69 ± 8 70 ± 5 0.76 64 ± 3 65 ± 4 0.75 LV mass index (g/m2) 152 ± 7 129 ± 8 <0.05 162 ± 4 124 ± 4 <0.05 RV parameters  RVEDD (mm) 33 ± 5 34 ± 4 0.