65) for RA compared with nonpersistent patients. Larger differences were observed in younger patients and in patients initiating treatment with high efficacy statins. In the OA cohort analysis, Fer-1 Metabolism inhibitor high persistence with statins was associated only with a modest decrement in risk ratio (hazard ratio = 0.85; 0.81-0.88) compared to nonadherent patients.\n\nConclusions:

The present study demonstrates an association between persistence with statin therapy and reduced risk of developing RA. The relationship between continuation of statin use and OA onset was weak and limited to patients with short-term follow-up.”
“In recent years, the intestinal flora has been shown to be a regulator of energetic metabolism. The functional links which unite the intestine and all the micro-organisms, which populate it result from a close symbiosis. Thus, mutualist ecology between the bacteria and the host confers a concurrent advantage, especially against external aggressions. At birth, the intestine is colonised by the surrounding micro-organisms. This association induces many physiological changes as the alimentary transition evolves, which enable the normal development of the intestine and the host. The intestinal microbiosis is necessary for the appropriate institution of vascular, nervous and immunological systems. The microflora

plays a major role in the metabolic transformation of nutrients, essential for the stability of the ecosystem but also Fer-1 ic50 very necessary for the host. Therefore, it is intuitive to imagine that, of the obvious advantages, which this association induces in the intestine, energetic metabolism is principally

implicated. Recent GSK1210151A inhibitor studies have demonstrated the essential role of the intestinal flora in maintaining ponderal and glucose homeostasis. Thus, when an unbalanced flora colonises a healthy host, it has been shown that this new association was responsible for excessive weight gain, the appearance of insulin resistance and of an episode of hyperglycaemia. Hence, a new era of therapeutic strategy has begun, during which the normalisation of an unbalanced intestinal microbiotopis by probiotics and prebiotics should improve energetic metabolism by the restoration of an intestinal ecology to the benefit of the host.”
“The genus Phyllomedusa has been the target of regular taxonomic investigations. The species Phyllomedusa nordestina was recently separated from P. hypochondrialis. Morphological variations in the P. rohdei interpopulation have already been reported, suggesting the existence of more than one taxon under that name. In the present study, we have cytogenetically characterized two populations of P. nordestina and one of P. rohdei. Both species displayed 2n = 26 chromosomes with 12 metacentric, 12 submetacentric and 2 subtelocentric chromosomes. The C-banding analyses revealed discrete differences in the quantity of centromeric heterochromatin between the two species.