Hippocampus was the most vulnerable region whereas the brainstem was the most resistant. Although not directly compared here, the regional pattern of SEND seems not to be altered by hypothermia treatment, but maintains its profile distinctive for cardiac arrest pathogenesis.

(C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of 10-O-dimethylaminoethylginkgolide B (XQ-1H), a protective agent against cardiovascular accident for its potential anti-platelet-activating factor activity, were investigated in rats. Plasma profiles were obtained after intravenous administration of 4, 8, 16, and 32 mg/kg of XQ-1H. There was a gender difference in the pharmacokinetics of XQ-1H. PF-562271 purchase The elimination half-life of XQ-1H was 209.55, 200.81, 236.95, and 269.78 min in female rats and was 139.63, 173.83, 191.28, and SNS-032 nmr 228.0 min in male rats at doses of 4, 8, 16, and 32 mg/kg, respectively. At four dose levels, female rats have higher values for area under the curve (AUC) than male rats. XQ-1H had linear pharmacokinetic characteristics in rats within the dose ranges tested. The

volume of distribution in rats ranged from 6.05 to 15.09 1/kg. XQ-1H showed an extensive distribution into multiple tissues and reached its maximal concentration in all tissues at 10 min post-dose. About 80% of XQ-1H was mainly converted to its hydrolyzed and demethylated metabolites in vivo, and the elimination of unchanged compound was minor (< 20%) in rats.”
“A novel oleanen type triterpenoid glycoside has been isolated from butanolic seed extracts of Cassia angustifolia. Its structure was elucidated as 3-O–D-glucuronopyranosyl-(1 4)-[-D-galactopyranosyl-(1 2)]–D-xylopyranosyl-(1 3)–D-glucopyranosyl-2, 16-dihydroxy-4, 20-hydroxy methyl olean-12-ene-28-oic acid on the basis of spectral evidence (i.e. FTIR, 1H NMR, 13C Bindarit molecular weight NMR and FAB-MS data). The isolated saponin was tested for its antifungal activity, where the maximum inhibition was found in Colletotrichium dematium.”
“The choice of surgical strategy for patients with proximal gastric cancer is controversial. The purpose of this study was to

assess the feasibility, safety, and surgical and functional outcomes of laparoscopy-assisted proximal gastrectomy (LAPG) and laparoscopy-assisted total gastrectomy (LATG).

Between June 2003 and December 2009, 131 patients with proximal gastric cancer underwent LAPG (n = 50) or LATG (n = 81) at Seoul National University Bundang Hospital. We reviewed their medical and surgical records from our prospectively collected gastric cancer database. The clinicopathologic characteristics and short-term, long-term, and functional outcomes were compared between the 2 groups.

There were no significant differences in demographics, T-stage, N-stage, or survival between the 2 groups. The LAPG group had a shorter operative time and lower estimated blood loss than the LATG group.