In addition, further studies are warranted to confirm the effects

In addition, further studies are warranted to confirm the effects of CKI on cancer stem-like cells of other cancer cell lines and primary carcinomas. Acknowledgements We thank Dr. Ma Shiliang (Peking University Health Science Center, Beijing, China) for assisting in cell sorting by FACS. This paper was supported by Grants No.30772867 from the National Nature Science Foundation of China and No.2006BAI04A05 from the Eleventh

Five-Year Program of the National Science and Technology Project. Electronic supplementary material Additional file 1: A representative fingerprint of CKI. A representative fingerprint of CKI showing 8 common peaks. Peak 3 is Oxymatrine, Peak 4 is Oxysophocarpine, Peak 6 is Matrine, and Peak 7 is Sophocarping. (TIFF 5 MB) References 1. Reya T, Morrison SJ, Clarke MF, Weissman IL: Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105–111.PubMedCrossRef Ruxolitinib 2. Gottesman MM: Mechanisms of cancer drug resistance. Annu Rev Med 2002, 53:615–627.PubMedCrossRef 3. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino

BP: The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant SAHA HDAC mw of the side-population phenotype. Nat Med 2001, 7:1028–1034.PubMedCrossRef 4. Bao S, Wu Q, Mclendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444:756–760.PubMedCrossRef 5. Graham SM,

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