In order to optimize self-nanoemulsifying drug delivery systems (SNEDDS), formulation dispersion-drug precipitation test was performed in the absence and presence of cellulosic polymers. Furthermore, SNEDDS was loaded onto liquisolid powders. GW4869 manufacturer P-glycoprotein (P-gp) activity of the selected SNEDDS was tested using HCT-116 cells. Carvedilol showed acceptable solubility in the selected excipients. It also demonstrated improvement in the stability upon dilution with aqueous media in the presence of cellulosic
polymers. Use of granulated silicon dioxide improved the physical properties of liquisolid powders containing SNEDDS. It improved the compressibility of the selected powders and the tested FK228 research buy SNEDDS showed marked P-gp inhibition activity. Prepared self-nanoemulsifying tablet produced acceptable properties of immediate-release dosage forms and expected to increase the bioavailability of carvedilol.”
“Objective: The primary aim of this study was to describe Japanese oncology nurses’ self-reported ability to assess and care for cancer patients’ mental health. A secondary aim was to describe nurses’ self-reported stress levels and need for stress management related to caring for oncology patients.
Methods:
This cross-sectional questionnaire study was conducted from September to November 2010 among cancer-care nurses participating in mental healthcare training. The questionnaire asked about assessment of patient anxiety, depression, delirium, anger, and acceptance, and included four statements about work-related stress. A 4-point Likert scale was used for responses.
Results: The 88 participants (86 women) ranged in age from the 20s to the 50s, with the greatest number in their 30s (47.2%, n=42). More than 50% of nurses were very concerned about assessing cancer patient anxiety and depression; approximately 20% were extremely concerned about caring for depression and
anger in patients. Overall, 83.2% (n=74) of cancer-care nurses felt distressed over their CH5183284 Angiogenesis inhibitor occupation, only 19.1% (n=17) stated that they were controlling their stress, and over half indicated a need for stress-management programs.
Conclusions: Nurses perceived that assessments of and care for the mental state of cancer patients were inadequate. Cancer-care nurses need training in assessing and caring for the mental state of cancer patients, as well as stress management training programs for themselves. Copyright (c) 2012 John Wiley & Sons, Ltd.”
“Study Design. A retrospective study of postoperative pain management.
Objective. Evaluate the efficacy and safety of continuous intravenous morphine infusion for postoperative pain management in patients with idiopathic scoliosis (IS) undergoing posterior spinal fusion (PSF) and segmental spinal instrumentation (SSI).
Summary of Background Data. Postoperative pain is a common problem following surgery for IS.