In the meantime, clinicians should, if they choose to attempt to prevent injury with orthoses, keep cost in mind. “
“Summary of: Troosters T et al (2010) Resistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 181: 1072–1077. [Prepared by Kylie Hill, CAP Editor.] Question: In patients with chronic obstructive pulmonary disease (COPD), hospitalised with an acute exacerbation, does resistance training preserve quadriceps muscle force or change markers of systemic inflammation or muscle metabolism? Design: Randomised

controlled trial with concealed allocation.

Neither the investigators nor the participants were blinded to group allocation. Setting: Tertiary hospital in Leuven, BTK inhibitor Belgium. Participants: Key inclusion criteria were: people with COPD, hospitalised with an acute exacerbation, aged <85 years, not hospitalised in the previous 14 days, not participating in a rehabilitation program, and no co-morbid conditions precluding participation in resistance training. Randomisation of 40 patients allocated equal numbers to the intervention and groups. Interventions: Both groups received standard doses of oral corticosteroids and physiotherapy limited to airway clearance techniques and breathing exercises. In addition, each day, the Bay 11-7085 intervention group performed three sets of eight repetitions

of quadriceps resistance exercise, www.selleckchem.com/products/cilengitide-emd-121974-nsc-707544.html at a load set at 70% of the one repetition maximum. The load was progressed according to symptoms of dyspnoea and fatigue. Training sessions were supervised by physiotherapists. Outcome measures: The primary outcome was maximum isometric quadriceps force. Secondary outcomes included six-minute walk distance (6MWD) and serum concentrations of C-reactive protein, testosterone and insulin-like growth factor-1. In a sub-group of patients (n = 20), gene expression for anabolism and catabolism were obtained via biopsy of vastus lateralis. Results: Data were available on 36 patients at the time of hospital discharge. At discharge, the mean difference in the magnitude of change in quadriceps force in the intervention group relative to the control group was 10.7% (95% CI 0.9 to 20.7%). The intervention group demonstrated a predominant expression of anabolic markers, whereas the control group tended to demonstrate a predominance of catabolic markers. There were no other significant between-group differences. Conclusion: Resistance training for patients with COPD who were hospitalised for an exacerbation preserved quadriceps force without increasing biomarkers of systemic inflammation.