Methods Protocol and registration This systematic Review has not been registered. The research objectives, analysis methods and inclusion criteria are fully specified here. Study eligibility criteria Retrospective and prospective studies of injured persons presenting to an emergency department in China were the focus of this Review. Studies that included all-cause injury presentations published from 1997 to 2007 in the Chinese language were included. Studies that focused exclusively on traffic crashes, age cohort subsets or

specific injuries were excluded from Inhibitors,research,lifescience,medical the Review. Information sources Studies were identified using electronic databases, a hand-search of the Tables of contents pages of general and specialist medical Chinese language journals (Table ​(Table1),1), and by scanning reference lists of identified articles. The initial search Inhibitors,research,lifescience,medical strategy

included both Chinese and English language articles within the limits specified above, with ‘Medline’ and ‘China Academic Journals Inhibitors,research,lifescience,medical Full-Text Database’ used. The last search was performed in 11 July 2009. Table 1 List of Journal outlets searched by hand Search strategy For the computerised searches the following search terms were used: ‘China’; ‘emergency medical services’; emergencies; emergency; ambulances; air Inhibitors,research,lifescience,medical ambulance(s); ‘emergency service, hospital’; ‘emergency department’; ‘pre-hospital care’; ‘wounds and injuries’; accident(s). Multiple searches (4) were conducted and duplicate articles were identified and Mdm2 signaling inhibitors eliminated. The same search terms and strategy was used in both electronic databases (Table ​(Table22 appendix). Table 2 Appendix – SEARCH STRATEGY – MEDLINE (OVID) Study selection

and classification of the identified research One Review author (MF) conducted the searches Inhibitors,research,lifescience,medical and with the assistance of Review Author JY classified each study according to its principal focus. A classification scheme was developed (refer Additional file 1 Table S1) with the number of published papers in each category noted (refer Additional file 2 Table S2). Figure ​Figure11 presents the identification, screening, eligibility ADP ribosylation factor assessment and included studies in accordance with the PRISMA specification [12]. Figure 1 Number of identified, screened, eligible and included original research articles in the review process. Data items of interest In seeking to fulfill the second aim of this Review, the patient characteristics, injury severity and outcome indicator data fields of interest were specified a-priori.