Methods:
Review of medical, audiological, and radiological records
Results An 8 year old female presented with bilateral moderate conductive hearing loss, bilateral microtia, left EAC stenosis, and right EAC atresia, secondary VX-680 mouse to prenatal isotretinoin exposure Comorbidities included developmental delay, ventricular septal defect, hypotonia, and retinal maldevelopment The left EAC was sharply upsloping with a 2 mm-diameter meatus. Computed tomography (CT) scan of the temporal bone demonstrated normal middle and inner ears bilaterally, serial CT scans over 6 years demonstrated progressive development of left canal cholesteatoma. Implantation of a right BAHA system was performed, followed by left canalplasty and excision of cholesteatoma with facial nerve monitoring An endaural incision was utilized to avoid compromising future microtia repair Postoperative left-sided hearing improved to mild low-frequency conductive hearing loss rising to normal at 2000 Hz and above.
Conclusions
Despite extensive precautions selleck compound for its use, isotretinoin remains a cause of major birth defects. including sensorineural, conductive or mixed hearing loss. Congenital EAC stenosis is much less common than congenital atresia or acquired stenosis, optimal surgical approaches vary depending on hearing status and facial nerve anatomy Close monitoring for development of canal cholesteatoma is necessary. (C) 2010 Elsevier Ireland Ltd All rights reserved”
“Background: The aim of the present study was to analyze hemodynamic changes after the administration of either 2% lidocaine with epinephrine 1: 100,000 (L100) or 4% articaine with epinephrine 1: 200,000 (A200) in the surgical removal of symmetrically positioned lower third molars.
Methods:
A prospective, randomized, HIF pathway double-blind, clinical trial was carried out involving 43 patients. Each patient underwent 2 surgeries on different occasions-one under local anesthesia with L100 and the other with A200. The following parameters were assessed at 4 different times: systolic, diastolic, and mean blood pressure; heart rate; oxygen saturation; rate pressure product (RPP); and pressure rate quotient (PRQ).
Results: No hypertensive peak was observed in systolic, diastolic, and mean blood pressure at any evaluation time. Moreover, the type of anesthetic solution did not affect diastolic blood pressure, oxygen saturation or PRQ during the surgeries. Statistically significant differences between groups were detected with regard to heart rate and RPP (P < 0.05).
Conclusions: The epinephrine concentration (1: 100,000 or 1: 200,000) and local anesthetic solutions used (2% lidocaine or 4% articaine) influenced hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar removal.”
“Objective.