SBP was associated with hepatic encephalopathy (HE) in 93(57.7%), Buparlisib cell line Variceal bleed (VB) in 16(9.9%), septic shock in 60(37.2%) requiring ventilator support in 47(29.2%) with median hospital stay of 7(range 4-14) days with a high mortality (n=43, 26.7%); predominantly due to sepsis (83.7%), Variceal bleed (11.7%). The predictors

of poor survival were presence of HE, Child-C status, MELD >24, persistence of SBP on D3 and D7, low ascitic fluid glucose <92mg/dl%, culture positivity for ascitic fluid (p<0.05). Reduction in ascitic fluid neutrophil count by 13% on D3, was the only predictor associated with improved survival (p<0.05). Conclusions:- The clinical presentation, advanced liver disease, low ascitic fluid glucose with culture positivity at the baseline and the neutrophil count reduction but not the base line ascitic fluid TLC or reduction at 48hr predict the resolution of SBP and overall outcome. The response tap at 48 hr showing neutrophil BAY 57-1293 count reduction by 13% is associated with better outcome Disclosures: The following people have nothing to disclose: Ashok K. Choudhury, Ankur Jindal, Chandan K. Kedarisetty, Tanmay S. Vyas, Ajeet S. Bhadoria, Shiv K. Sarin Purpose : To analyze the impact of TIPS with covered stents on survival of patients with

“severe” portal hypertension compared to a control group treated medically. To assess complications associated with implantation of the TIPS. Material and methods : 344 consecutive patients were hospitalized for decompensated cirrhosis (Child-Pugh B 60% / C 40%) from 01/2008 to 12/2012. Covered stent was implanted in 98 patients for refractory ascites or recurrent gastrointestinal

bleeding. Assessment of median survival (MS) with and without TIPS, MS according to Child-Pugh score and after matching 1:1 (n=130) for age, Child-Pugh score, MELD score, presence of hepatocellular carcinoma HCC, to a control group having a first decompensation. Results :TIPS implantation was successful in 100% of rates. The mean portosystemic pressure gradient decreased from 18.5±4.5 mmHg to 5.8±2.6 mmHg. MS of patients with TIPS (n=98) was 29.4 months [22-38.6] vs. 12.9 months [10.2-18.3] without TIPS (n=246), p=0.0015 ; MS of child-pugh B patients with TIPS (n=69) was 38.6 months [29.4-48.7] vs. 19.1 months [14.1-35.3] without TIPS (n=137), p=0.0183; medchemexpress MS of child-pugh C patients with TIPS (n=29) was 17.4 months [10.1-25.3] vs. 8 months [6.2-11.2] without TIPS (n=109), p=0.22. TIPS was a prognostic variable associated with survival in univariate analysis (p=0.015). HCC, alcoholic hepatitis were more frequent in patients without TIPS (respectively 31% vs. 8%, p <.0001, 17% vs. 10%, p=0.05). After matching 1:1 for age (61 ±10), Child-Pugh score (B 66%, C 34%), MELD score (17.0±4.2) and presence of HCC (9%), esophageal varices grade 2 or 3 (p=0.003), refractory ascites (p=0.01), an increase in the portosystemic gradient (p=0.