Studies of Se status in relation to adiposity are scarce in the United Kingdom. This study examined cross-sectional associations of anthropometric indices with Se-status biomarkers in a nationally representative sample of 1045 selleck chemicals llc (577 female, 468 male) British Caucasian adults ages 19-64 who participated in the 2000-2001 National Diet and Nutrition Survey. Median (first, third quartile) values for whole-blood glutathione
peroxidase (GPx) activity and plasma and erythrocyte Se concentrations were 120.0 (103.0, 142.4) nmol mg Hb(-1) min(-1), 1.08 (0.98, 1.20) mu mol/L, and 1.62 (1.38, 1.91) mu mol/L, respectively. For males, values were 119.0 (100.0, 141.0) nmol mg Hb(-1) min(-1), 1.09 (0.99, 1.22) mu mol/L, and 1.54 (1.34, 1.79) mu mol/L, respectively; for females 121.0 (105.0, 145.0) nmol mg Hb(-1) min(-1), 1.07 (0.97, 1.18) mu mol/L, and 1.71 (1.43, 1.99) mu mol/L, respectively. Multivariate adjusted mean differences (95% CI) in whole-blood GPx between the highest ( bigger than 30 kg/m(2)) and the lowest ( smaller than 25 kg/m(2)) categories of body mass index and the highest (96.5-139.2 cm) and the lowest (52.2-78.1 cm) quartiles of waist circumference (WC)
were -7.9 (-13.2, -2.7) and -9.7 (-16.2, -3.2) nmol mg Hb(-1) min(-1), respectively. Difference (95% CI) in plasma Se between the third (87.5-96.4 cm) and the lowest JNJ-26481585 inhibitor quartiles of WC was -0.04 (-0.08, -0.03) mu mol/L. Difference (95% CI) in red blood cell (RBC) Se between the highest (0.91-1.11) and the lowest (0.53-0.76) quartiles of waist-to-hip ratio (WHR) was 0.10 (0.00, 0.20) mu mol/L. Similar results were observed us gender and menopausal-status subgroup analyses. The inverse association between plasma Se and WC and the positive association between RBC Se and WHR will need confirmation. The findings suggest associations between low whole-blood GPx activity and higher measures of general and central adiposity. Further experimental
and randomized studies are needed to deduce the mechanisms and infer causality. (C) 2013 Elsevier Inc. All rights reserved.”
“To explore the potential therapeutic effects of angiotensin(1-7) (Ang(1-7)), an endogenous ligand of the Mas receptor, on streptozotocin-induced diabetic nephropathy, ISRIB mw male Wistar rats were randomly divided into two groups: a control group and a diabetic model group. After 12 weeks, the diabetic rats were divided into subgroups for 4-week treatments consisting of no-treatment group, small-, moderate-, and large-dose Ang(1-7) groups, a valsartan group, a large-dose Ang(1-7) plus valsartan group, and an A779 (antagonist of the Mas receptor) group, each with 15 rats. Ang(1-7) improved renal function, attenuated glomeruli sclerosis, oxidative stress, and cell proliferation, decreased the expression of collagen IV, TGF-beta 1, VEGF, NOX4, p47phox, PKC alpha, and PKC beta 1, and the phosphorylation of Smad3.