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“The objective of this work was to apply a new apparatus for the assay of the drug release from lozenge tablet with a potential use in the treatment of oral candidosis and another conditions connected to microbial etiopathology in the oral cavity or as an antiplaque factor. Also, an approach

to comparison of the applied method with the classical paddle apparatus method was performed. Tablets containing chlorhexidine dihydrochloride check details were formulated with granulated sorbitol of different grades (diameter of 110, 180, 480, and 650 mu m, respectively), lactose, and magnesium stearate as excipients. Tablets were obtained through direct compression, and uniformity of weight, friability, breaking strength, disintegration, and release rate were evaluated. The disintegration times ranged between 10 and 21 min. In the next stage of the study, the release of chlorhexidine from lozenges prepared with granulated sorbitol grade 110 mu m and different amounts of lactose

and magnesium stearate was assessed. Two stages were observed during the release of chlorhexidine dihydrochloride from the lozenges, assayed by the classical paddle apparatus method II USP. In the first selleck screening library stage, release rates were between 2.6 x 10(-2) and 4.7 x 10(-2) min(-1), in the second stage between 1.7 x 10(-3) and 7.7 x 10(-3) min(-1). In the case of the in-house method, the release was near to first-order kinetics through the entire release experiment, with rate constants between 3.6 x 10(-2) and 6.6 x 10(-2) min(-1). The sorbitol granulate of granules with diameter 110 mu m was found to be most suitable for the lozenges with chlorhexidine dihydrochloride and lactose. The in-house release method, proposed in this work, seems to be more realistic for the preliminary assessment of predicted drug concentrations in the oral cavity after the intake of a lozenge.”
“Highly efficient single-layer organic light-emitting diodes with reduced efficiency roll-off are demonstrated by using a bipolar host material of 2,5-bis(2-(9II-carbazol-9-yl)phenyl)-1,3,4-oxadiazole (o-CzOXD) doped with iridium

complexes as the emissive layer. For example, the green single-layer device, employing fac-tris(2-phenylpyridine) iridium Ir(ppy)3 as dopant, shows a peak current efficiency of 45.57 cd A(-1), corresponding to external quantum find more efficiency (EQE) of 12.42%, and still exhibits efficiencies of 45.26 cd A(-1) and 40.42 cd A(-1) at luminance of 1000 and 10 000 cd m(-2), respectively. In addition, the yellow and red single-layer devices, with bis(2-(9,9- diethyl-9H-fluoren-2-yl)-1-phenyl-1H-benzoimidazol-N, C-3) iridium (acetylacetonate) (fbi)(2)Ir(acac) and bis(1-phenylisoquinolinolato-C-2, N)iridium(acetylacetonate) (piq)(2)Ir(acac) as emitter, also show high EQE of 7.04% and 7.28%, respectively. The transport properties of o-CzOXD film are well investigated by current-voltage measurement, from which both hole and electron mobility are determined.