“
“Two callosotomized patients and 24 neurologically normal subjects performed simple binary discriminations between upright letters flashed in one or other visual field. Where discrimination of the letters F and R by name either showed a left-hemisphere advantage or no hemispheric effect, discrimination of whether the same letters were normal or backward showed 8-Bromo-cAMP a right-hemisphere advantage. These results suggest that discrimination of mirror-image letters depends on matching to

an exemplar, for which the right-hemisphere is dominant, while letter naming depends on abstract category recognition. One commissurotomized patient, DDV, showed systematic left-right reversal RG-7388 datasheet of the letters in the left visual field, classifying the normal letters as reversed and reversed ones as normal, and persisted with this reversal when the letters were shown in free vision. This suggests that reversed exemplars of the letters may be laid down the right cerebral hemisphere. There was no such reversal in the other patient (DDC). (C) 2010 Elsevier Ltd. All rights reserved.”
“The DNA genome of hepatitis B virus (HBV) replicates via reverse transcription within capsids following the encapsidation of an RNA template, the pregenomic RNA (pgRNA). We previously demonstrated that the 5′ cap proximity of the stem-loop structure (epsilon or epsilon), an

encapsidation signal, is critically important for the encapsidation of the pgRNA (J. K. Jeong, G. S. Yoon, and W. S. Ryu, J. Virol. 74: 5502-5508, Cepharanthine 2000). Therefore, we speculated that the viral polymerase (Pol), while bound to the 5′ epsilon stem-loop structure, could recognize the cap via its interaction with eIF4E, a eukaryotic translation initiation factor. Our data showed the direct interaction between HBV Pol and eIF4E, as measured by coimmunoprecipitation.

Further, we demonstrated that eIF4E interacts with the Pol-epsilon ribonucleoprotein complex (RNP) rather than Pol alone, resulting in eIF4E-Pol-epsilon RNP complex formation. In addition, we asked whether eIF4E remains engaged to the Pol-epsilon RNP complex during nucleocapsid assembly. Density gradient analysis revealed that eIF4E indeed was incorporated into nucleocapsids. It is of great importance to uncover whether the incorporated eIF4E contributes to viral reverse transcription or other steps in the HBV life cycle.”
“This study examined the nature of deficits in mentalizing, the ability to read the mental state of other people, as measured by a faux pas task in people with medial frontal lesions. A total of 56 Mandarin-speaking Chinese individuals participated (9 participants with medial frontal lesions, 12 participants with lateral frontal lesions, 5 participants with non-frontal lesions, and 30 healthy controls).