Consistent SZ scored significantly worse than HC on all RBANS scales except for language. It should be noted that laboratory DD results, demographic characteristics, and cognitive assessments for all imaging participants of this study (except one inconsistent SZ) were included in the larger samples of HC and SZ in R. E. Weller, K. B. Avsar, J. E. Cox, M. A. Reid, D. M. White, A. C. Lahti (unpubl. ms). The inconsistent SZs for whom Pacritinib FLT3 quality scans were available (n = 9) did not differ from the consistent SZ group on any of the demographic variables, BPRS or RBANS scores, with the exception of the Delayed Memory score of the Inhibitors,research,lifescience,medical RBANS where inconsistent SZ scored worse than

Consistent SZ (Table S4). By definition, inconsistent SZ had lower R2 (mean = 0.26) than consistent SZ and HC but also significantly higher log(k)

(mean = −0.019). Inhibitors,research,lifescience,medical However, the validity of the computed k values for this group is suspect. Inspection of Figure ​Figure5,5, left, reveals that percentage of Now responses (%Now) by inconsistent SZ was significantly higher for k5 trials than for the other groups, consistent with greater DD, but %Now was also significantly lower versus HC for k1 trials, contrary to what would be expected for more impulsive individuals. Furthermore, %Now values from individual inconsistent SZ (Fig. ​(Fig.5,5, right) reveal that a large percentage failed to show the expected pattern of decreasing Inhibitors,research,lifescience,medical %Now as trial k’s increased, suggesting that the task

was Inhibitors,research,lifescience,medical too difficult and/or that the participants were not meaningfully engaged in the task. Figure 5 Mean (± standard error) percentage of Now (%Now) choices as a function of the five trial k’s for the consistent healthy controls (HC), consistent SZ, and inconsistent SZ (INCON) (left) and for individual inconsistent SZ (n = 9; right). a, P = … It should be noted that in our behavioral study of performance on the laboratory version of the DD task (R. E. Weller, K. B. Avsar, J. E. Cox, M. A. Reid, D. M. White, A. C. Lahti, unpubl. ms.), almost all (21/23) the SZ participants Inhibitors,research,lifescience,medical in this study had met the same criterion level of consistency used in this study, R2 Brefeldin_A > 0.60. However, the laboratory task is undoubtedly easier than the magnet task, consisting of fewer trials and with a higher percentage of easy trials, on which the subjective values of the two choices are markedly different. In addition, participants often find the magnet environment to be stressful. The inability of approximately 40% of previously consistent SZ to appropriately perform the task in the magnet may be attributable to this combination of greater difficulty and stress (Mazure 1995). Those SZ who switched from consistent in the laboratory to inconsistent in the magnet had significantly lower R2, as well as higher log(k) in the laboratory session than those who remained consistent.