Methods: 5 obesity model dogs as treatment group were performed endoscopic Esophagus-Jejunum stent bypass (combined with laparotomy), and 5 normal dogs as control group were performed endoscopy and exploratory laparotomy. The weight change indicators (body mass, abdominal MEK inhibitor circumference, Lee index) were
determined of preoperatiivly, and 4 weeks, 8 weeks, 12 weeks postoperatively, respectively. Results: All dogs were the successful implementation of operation, no significant complication observed, and no dog dead, but foodintake Reduced obviously in treatment group dogs. The decline of body mass, abdominal circumference, and Lee index was observed at 4 week in treatment group, and more significantly at 12 week postoperatively. (preoperative body mass, abdominal circumference, and Lee index were 19.90 ± 0.84 kg, 41.80 ± 2.77 cm, 389.53 ± 9.57, vs. 18.10 ± 0.87 kg, 39.4 ± 1.05 cm, 373.47 ± 9.44 at 4 week, P < 0.05; vs. 15.02 ± 0.53 kg, 32.00 ± 1.50 cm, 355.17 ± 12.37 at 12 week postoperatively, P < 0.01); but the change of above indicators was not obvious in control group. Preoperative body mass, abdominal circumference, and Lee index all were higher http://www.selleckchem.com/products/sch772984.html in
treatment group than in control group significantly, no statistical differences at 12 week postoperatively. Conclusion: Endoscopic Esophagus-Jejunum stent implantation bypass which simulate and improve of classic Roux-en-Y gastric bypass can treat obesity effectively and
safely. Key Word(s): 1. Obesity; 2. Endoscopy; 3. Stent; 4. Bariatric surgery; Presenting Author: SUOLIN FU Additional Authors: HUIMING ZHU, LI ZHENG Corresponding Author: SUOLIN FU Affiliations: Nanchang University; Jinan University Objective: To observe and evaluate the effect of endoscopic Esophagus-Jejunum stent bypass treatment on type 2 diabetes mellitus (T2DM) model dogs. Methods: 5 dogs of T2DM model as treatment group were performed endoscopic Esophagus-Jejunum stent bypass (combined with laparotomy), and 5 normal dogs as control group MCE were performed endoscopy and exploratory laparotomy. The T2DM indicators including fast plasm glucose (FPG), fasting insulin (FINS) and intravenous glucose tolerance (IVGTT) were determined preoperatively, and 4 weeks, 8 weeks, 12 weeks postoperatively, respectively. Results: FPG, IVGTT-2h PG, FINS and IVGTT-2h FINS all dropped obviously at 4 week postoperatively in treatment group, and were significantly lower than preoperatively (P < 0.01). It fell near to which in controls, and no no statistical difference between treatment group and control group at 12 week postoperatively (P > 0.05). The IR index distinctly dropped and the HOMA-βshowed a rise trend after operation in treatment group. Conclusion: Endoscopic Esophagus-Jejunum stent implantation bypass which simulate and improve of classic Roux-en-Y gastric bypass can treat T2DM effectively and safely. Key Word(s): 1. T2DM; 2. Endoscopy; 3. Stent; 4.