Mûr, Dr A. Payà, Dr M. A. López-Vilchez and Dr R. Carreras (Hospital del Mar, Universidad EPZ015666 manufacturer Autonoma, Barcelona, Spain); Dr N. H. Valerius and Dr V. Rosenfeldt (Hvidovre Hospital, Hvidovre, Denmark); Dr O. Coll, Dr A. Suy and Dr J. M. Perez (Hospital Clínic, Barcelona, Spain); Dr C. Fortuny and Dr J. Boguña (Hospital Sant Joan de Deu, Barcelona, Spain); Dr V. Savasi, Dr S. Fiore and Dr M. Crivelli (Ospedale L. Sacco, Milan, Italy); Dr A. Viganò, Dr V. Giacomet, Dr C. Cerini, Dr C. Raimondi and Professor G. Zuccotti (Department of Pediatrics, L. Sacco Hospital, University of Milan, Milan, Italy); Dr S. Alberico, Dr M. Tropea and Dr C. Businelli (IRCCS

Burlo Garofolo, Trieste, Italy); Dr G. P. Taylor and Dr E. G. H. Lyall (St Mary’s Hospital, London, UK); Ms Z. Penn (Chelsea and Westminster Hospital, London, UK); Drssa W. Buffolano and Dr R. Tiseo (Pediatric Dept, Federico II University,

Naples, Italy), Professor P. Martinelli, Drssa M. Sansone, Dr G. Maruotti and Dr A. http://www.selleckchem.com/products/GDC-0941.html Agangi (Obstetric Dept, Federico II University, Naples, Italy); Dr C. Tibaldi, Dr S. Marini, Dr G. Masuelli and Professor C. Benedetto (University di Torino, Torino, Italy); Dr T. Niemieç (National Research Institute of Mother & Child, Warsaw, Poland); Professor M. Marczynska, Dr S. Dobosz, Dr J. Popielska and Dr A. Oldakowska (Medical University of Warsaw, Infectious Diseases Hospital, Warsaw, Poland); Dr R. Malyuta, Dr I. Semenenko and Ms T. Pilipenko (ECS Ukraine co-ordinating centre). “
“The aim of the study was to describe the relationship between preterm delivery (PTD; < 37 weeks of gestation)

and antiretroviral Buspirone HCl therapy in a single-centre cohort of pregnant women with HIV infection. A retrospective analysis of data for 331 women who received care in a dedicated HIV antenatal clinic between 1996 and 2010 was carried out. Data on first CD4 cell count and viral load (HIV-1 RNA copies/mL) recorded in pregnancy, class and timing of antiretroviral therapy, gestational age at delivery, and risk factors for and causes of PTD were available from a clinical database. Overall, 13.0% of deliveries were preterm, of which 53% were severe preterm (< 34 weeks of gestation). The lowest rate of PTD was observed in women treated with zidovudine monotherapy (6.2%). Higher rates of PTD were observed in women starting combination antiretroviral therapy (cART) in pregnancy compared with women conceiving while on cART [odds ratio (OR) 2.52; 95% confidence interval (CI) 1.22–5.20; P = 0.011]. Of the women who were eligible for zidovudine monotherapy on the basis of CD4 counts and HIV viral load but who were treated with short-term cART to prevent HIV mother-to-child transmission, 28.6% delivered preterm. Women on short-term cART remained at the highest risk of PTD compared with zidovudine monotherapy in multivariate analysis (OR 5.00; 95% CI 1.49–16.79; P = 0.015). The causes of PTD are multiple and poorly understood.