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“OBJECTIVE AND IMPORTANCE: To report the treatment of a symptomatic giant basilar artery aneurysm in a child.

CLINICAL PRESENTATION: A 7-year-old girl presented with a 2-month history of progressive right hemiparesis caused by a huge fusiform aneurysm of the basilar artery with compression of the brainstem.

INTERVENTION OR TECHNIQUE:

Selleck AZD2281 The patient was treated with a bridging bare stent and occlusion of the stent lumen with detachable coils.

CONCLUSION: The patient experienced immediate total occlusion of the aneurysm with almost total recuperation after 1 year.”
“The goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population

and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included Selleck CHIR 99021 marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality. Effect modifiers of the age-walking speed association included extraversion (< 55 years, p = .019) and education (< 55 years, p = .021; >= 55 years, p = .012) in women, and openness (< 55 years, p = .005), waist circumference (< 55 years, p = .010), and subjective health (< 55 years, p = .014) in men. The strong impact of personality suggests that certain personality traits may be associated with behaviors that affect physical performance and condition the reduced mobility mostly at younger ages. If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention.”
“OBJECTIVE: We report a case in which fractionated gamma knife radiosurgery was used to treat

a metastatic melanoma lesion. The tumor demonstrated a rapid response to radiosurgery with an observable reduction in tumor volume between the second and third treatments, requiring a favorable modification in the third fractionated treatment.

CLINICAL PRESENTATION: A 61-year-old woman presented Sinomenine with a frontal floor metastatic melanoma lesion that was located adjacent to the optic apparatus.

INTERVENTION: Gamma knife radiosurgery was administered in three fractionated treatments of 6.5 Gy to the 50% isodose line in each case. Repeat imaging for the purpose of planning demonstrated that tumor volume at the time of the third treatment, 9 days following the first treatment, had decreased by 31%, resulting in a 21% decrease in the dose administered to the optic chiasm.

CONCLUSION: A case of metastatic melanoma treated with fractionated GKRS is presented, in which a significant reduction in tumor volume was noted 9 days following the initial treatment.