Patients mechanically ventilated preoperatively were excluded. A stepwise logistic regression model was used to test for the independent influence of various
perioperative factors on extubation in the operating room.
Results: Overall, 79% of patients were extubated in the operating room. Younger age and longer cardiopulmonary bypass time were the strongest predictors Pexidartinib research buy for not extubating. Each step down to a younger age group (< 2, 2-4, 4-6, 6-12, > 12 months) reduced the chance of extubation in the operating room by 56%. Cardiopulmonary bypass time for more than 150 minutes was associated with an 11.8-fold increased risk of not being extubated.
Male gender and high inotrope requirement after cardiopulmonary bypass were also significantly associated with fewer children being extubated.
Conclusion: Extubation in the operating room after surgery for congenital heart disease was successful in the majority of patients. The strongest independent risk factors for failure of this strategy included younger age and longer cardiopulmonary bypass time.”
“Objective: The risk of death during the interstage period remains high
after stage 1 reconstruction for single ventricle lesions, despite improved surgical results. The purpose of this study is to identify risk factors for interstage death and to describe the events leading to interstage death.
Methods: A nested case-control study was conducted of 368 patients who underwent stage 1 reconstruction at a single center between January 1998 and April 2005.
Results: Among the 313 (85%) hospital survivors, there were 33 (10.5%) interstage Tideglusib deaths. Cases more frequently presented with intact or restrictive atrial septum (9
[27%] vs 4 [4%]; P <.001), were older at the time of surgery (5[2-40] vs 3 [ 1 42] days; P = .005), had more postoperative arrhythmias (12 [36%] vs 15 [15%]; P = .01), and a higher incidence of airway or respiratory complications (12 [36%] vs 19 [19%]; P Topoisomerase inhibitor = .04). By multivariate analysis, only intact atrial septum ( odds ratio 7.6; 95% confidence intervals 1.9-29.6; P = .003) and age at operation greater than 7 days ( odds ratio 3.8; 95% confidence intervals 1.3-11.2; P = .017) were predictors of interstage death.
Conclusions: The presence of intact atrial septum and older age at the time of surgery are associated with a higher risk of interstage death. In addition, postoperative arrhythmia and airway complications are associated with a higher risk of interstage death in univariate analysis. The results of this study provide a focus for interstage monitoring and risk stratification of these high-risk infants, which may improve overall survival.”
“Objectives: Our objective was to determine the relationship between functional outcome and abnormalities of heart rate and rhythm after the Fontan operation.