622 d for all pentamidine recipients), including 6% who died of pentamidine toxicities [one proven postmortem to have a (non-functional) homozygous CYP2C19*2 mutation]. Charges for care attributable to pentamidine

toxicity exceeded what preemptive genotyping would have cost by 73-fold. These findings encourage routine use of preemptive CYP2C19 genotyping in alloSCT patients considered for pentamidine.”
“The shock compression response of several THV-alumina particle composites (where THV is a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinyldiene fluoride) was investigated based on experiments performed in the pressure range of 2-6 GPa. The composites, composed of 25% by volume of either 1, 10, or 100 mu m Al(2)O(3), had varying degrees of porosity. The high level of porosity,

particularly in the 1 mu m Al(2)O(3) composite, obscured determination of any particle size effects. In general, the composites displayed a stiffer GSK461364 in vitro shock response than expected, based on the known response of the constituent materials, with the 10 mu m Al(2)O(3) composite being slightly stiffer than the 100 mu m composite. CCI-779 It is argued that a possible way to describe the stiffer shock compression response is by assigning a higher value for the “”effective”" Gruneisen parameter gamma to the composites. The higher value is consistent with arguments made in the literature that gamma for polymers is much GDC-0449 higher (by as much as

an order of magnitude) than the often reported values (generally similar to 1 or less for polymers). The particle size effect can, however, possibly explain the difference in the stiffness between 10 and 100 mu m Al(2)O(3) composites, which is consistent with results reported in the literature. (C) 2011 American Institute of Physics. [doi:10.1063/1.3525761]“
“Background:

There is lack of knowledge to what degree clinical/morphological presentation and course of IgA nephropathy (IgAN) prior to end-stage renal disease are risk factors for graft loss after kidney transplantation.

Material and Methods:

Patients with IgAN between 1988 and 2006 (registered in the Norwegian Kidney Biopsy Registry) who later received a kidney transplant (registered in the Norwegian Renal Registry) were included. The cohort was followed up regarding death-censored graft loss throughout 2008. Graft survival with a rapid progressive (RP) vs. a slow progressive (SP) course of pre-Tx IgAN (annual GFR > or < 30 mL/min/1.73 m2) was studied.

Results:

Among 106 included patients, there were 14 graft losses giving a graft loss rate of 1.9/100 patient years. Follow-up until the first kidney transplant was 6.9 +/- 4.4 (range 0.1-19) yr. Patients with pre-Tx RP had a higher graft loss rate compared with SP patients (6.3 vs.1.3/100 patient years, p < 0.001). Graft loss rate with living-related donor (LRD) was similar to unrelated donor (UD) grafts.

From these results, the nano-ZnO hybrid sizing had good UV-aging shielding efficiency for PBO fiber. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 2468-2476, 2011″
“Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 EPZ004777 in vitro surgically resected intracranial

meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). PS-341 in vivo Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p = 0.046, p = 0.014). An HGF expression was statistically significant in the recurrent meningiomas (p = 0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p = 0.034). Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression

can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with

anaplastic progression.”
“The success of kidney and liver transplantation is hindered by a shortage of organs available for transplantation. Although currently illegal in nearly all parts of the world, a living ‘donor’ or ‘vendor’ kidney market has been proposed as a means to reduce or even end this shortage. Physician members of the American Society of Transplantation, the American Society of Transplant Surgeons and the American Association for the Study of Liver Disease were surveyed regarding organ markets for both living kidney and living liver transplantation. selleck The survey queried respondents about their attitudes toward directed living donation, nondirected living donation, the potential legalization of living donor organ markets and the reasons for their support or opposition to organ markets. Partial or completed surveys were returned by 346 of 697 eligible respondents (50%). While virtually all supported or strongly supported directed living donation (98% and 95% for kidney and liver lobes, respectively), the vast majority disagreed or strongly disagreed with the legalization of living donor organ markets (80% for kidneys and 90% for liver lobes). Both those who support and those who oppose a legalized living donor organ market rate risk to the donor among the most important factors to justify their position.

The expression of HAHB10 and of the flowering genes HASEP3 and HAFT was up-regulated by both salicylic acid (SA) treatment and infection with a virulent strain of Pseudomonas syringae. Basal SA and jasmonic acid (JA)

levels in Arabidopsis plants ectopically expressing HAHB10 were similar to those of control plants; however, SA levels differentially increased in the transgenic plants after wounding and infection with P. syringae while JA levels differentially decreased. Taken together, the results indicated that HAHB10 participates in two different processes in plants: the transition from the vegetative to the flowering stage via the induction of Givinostat cell line specific flowering transition genes and the accumulation of phytohormones upon biotic stresses.”
“Electronic structure of oxygen vacancies in Ta2O5 have been studied theoretically by first-principles calculations and experimentally by x-ray photoelectron spectroscopy. Calculations

of delta-Ta2O5 were performed using density functional theory within gradient-corrected approximation with the +U approach. Results indicate that the oxygen vacancy causes a defect level in the energy gap at 1.2 eV above the top of the valence band. To produce oxygen vacancies, amorphous films of Ta2O5 were bombarded with Ar+ ions. XPS results indicate that the Ar-ion bombardment leads to the generation of the oxygen vacancies in Ta2O5 that characterize the peak at 2 eV above the valence band. The calculated spectrum of crystalline delta-Ta2O5 demonstrates qualitative correspondence with the XPS spectrum of the amorphous Z-VAD-FMK manufacturer Ta2O5 film after Talazoparib Ar-ion bombardment. (C) 2011 American

Institute of Physics. [doi: 10.1063/1.3606416]“
“Starting from the case of a 12-year-old boy with dyskinetic (athetoid-dystonic subtype) cerebral palsy, the authors apply the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY) of the World Health Organization (WHO) as a comprehensive documentation tool to guide the pathway of care and illustrate a multidisciplinary and interdisciplinary neurorehabilitation team approach. The ICF-CY provides a common and universal language for describing and measuring health and disability in the first 2 decades of life. Despite the fact that this is a single case design, the authors consider it useful for the identification of an ICF-CY core set for the description of children with cerebral palsy. The results of this single case study are preliminary and need to be tested in a large trial of children with cerebral palsy.”
“From screening a population of Arabidopsis overexpression lines, two Arabidopsis genes were identified, EFO1 (EARLY FLOWERING BY OVEREXPRESSION 1) and EFO2, that confer early flowering when overexpressed. The two genes encode putative WD-domain proteins which share high sequence similarity and constitute a small subfamily.

8 [1.0 to 3.0]) and 6 months (adjusted hazard ratio, 2.3 [1.3 to 4.1]). Serial measurements of GDF-15 at randomization

and 6 months helped to identify patient cohorts at different levels of risk, with patients with persistently elevated GDF-15 levels > 1800 ng/L having the highest rate of the composite end point.

Conclusions – GDF-15 is independently related to adverse events in non-ST-segment-elevation acute coronary syndrome both in the acute setting and for at least 6 months after clinical stabilization. Therefore, continued research on GDF-15 should be focused on the usefulness of GDF-15 for support of clinical management in acute and chronic ischemic heart disease. (Circ Cardiovasc Genet. 2010;3:88-96.)”
“Objective: Evaluation of a neonate for suspected early neonatal sepsis routinely includes blood EPZ004777 research buy tests such as complete blood count, C-reactive protein (CRP) and culture. In order to obviate the need for venepuncture, we prospectively compared these tests in paired samples from umbilical cord and peripheral venous blood drawn during the first hours buy BTSA1 after birth in both preterm and term

infants.

Methods: Paired blood samples were studied from asymptomatic neonates with risk factors for early sepsis. Data were collected on maternal and neonatal factors that may have influenced the correlation between the tests.

Results: Three hundred fifty pairs of samples were studied. Significant correlation between umbilical cord and peripheral venous samples was found for white blood cell (WBC; r = 0.683) and platelets (PLT) (r = 0.54). Correlation for hemoglobin was lower (r = 0.36). No cases of early neonatal sepsis were detected. However, contamination rates were 12% in umbilical cord blood and 2.5% in peripheral venous blood cultures. WBC rose after birth and the 90th percentile rose

from 22 500 in umbilical cord blood to 29 700 in peripheral blood.

Conclusions: Screening for sepsis with umbilical cord CBC may be useful provided normal ranges are adjusted accordingly.”
“Background -The General Cardiovascular Risk Profile is a multivariable model that predicts global cardiovascular selleck inhibitor disease risk. Our goal was to assess the ability of the General Cardiovascular Risk Profile to identify individuals with advanced coronary artery calcification (CAC) and determine whether identification is improved with family history.

Methods and Results – Using data from the Multiethnic Study of Atherosclerosis, 3 sex-specific models were developed with ordinal logistic regressions to relate risk factors to CAC scores. Model 1 included covariates in the General Cardiovascular Risk Profile.

In addition, serum IL-17A concentration was significantly Ion Channel Ligand Library purchase increased in pneumonia patients. Integrin alpha 9 beta 1 levels positively correlated with serum IL-17A and CD18 expression levels. Conclusions: These findings suggest a potential role of integrin alpha 9 beta 1 expressed in neutrophils and elevated serum IL-17A in extravasation of neutrophils in cases of aspiration pneumonia. Copyright (C) 2012 S. Karger AG, Basel”
“Background:

Interest in subthreshold psychiatric disorders has increased recently. Diagnostic orphans experience one to two criteria of alcohol dependence but do not meet the diagnostic criteria for a DSM-IV alcohol use disorder (AUD). This study investigated the impact of subthreshold alcohol symptoms on three domains: physical illness, drinking patterns, and the occurrence of negative life events.

Method: Current drinkers (n = 26,946) in Copanlisib cost the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were divided into five diagnosis groups: no-AUD; one-criterion orphans (reference group), two-criterion orphans, alcohol abuse, and alcohol dependence. Exploratory

factor analysis examined the factor structure of items in the Alcohol Use Disorders and Associated Disabilities Interview Schedule (AUDADIS-IV) relating to each life domains. Factors were related to the diagnosis groups and background covariates using latent variable modeling.

Results: One-criterion orphans did not differ from the other groups with regards to physical illness. One- and two-criterion orphans differed significantly in relation to drinking patterns, with the latter group engaging in hazardous drinking behaviours more frequently. The dependence group were more likely to experience higher estimates of social problems compared to one-criterion orphans. One-criterion orphans were more likely than the abuse group to experience financial problems but less likely than the dependence

group to experience family-related legal problems.

Conclusions: Diagnostic orphans were more impaired than those with no-AUD or alcohol abuse in specific life domains; however, diagnostic orphans were significantly less impaired than those with alcohol dependence. Diagnostic orphans may be an important group for early ease identification and Salubrinal ic50 intervention. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Hugh M. Gloster, MD, has indicated no significant interest with commercial supporters.”
“Background: Treatment of chronic pulmonary sarcoidosis (CPS) is challenging and often requires long-term therapy with systemic corticosteroids and supplementary use of steroid- sparing agents. Objective: To examine the efficiency and safety of mycophenolate mofetil (MMF) as a steroidsparing agent in patients with CPS. Methods: We conducted a retrospective study of patients with biopsy-proven pulmonary sarcoidosis, who were treated with MMF and systemic corticosteroids for > 6 months between 2004 and 2010.

So, we systematically used x-ray combined analysis, a recently developed methodology which gives access to precise determination of the structure (cell parameters and space group) of the films, their orientation distributions (texture strengths and types) and mean crystallite

sizes, their residual stresses. This fine structural analysis shows important modifications between the film qualities which induce differences in BST films electrical behavior, permittivity, loss tangent, and tunability. (C)2011 American Institute of Physics. [doi:10.1063/1.3592282]“
“Objective. The aim of this study was to compare GPX instruments and hand files for gutta-percha removal.

Study design. Fifty maxillary central incisors with a single straight canal were selleck screening library instrumented and filled. The teeth were divided into 5 groups of 10 specimens each, according to the gutta-percha removal techniques: group 1: GPX (21-mm-long teeth); group 2: PD173074 datasheet GPX and xylol as solvent (21-mm-long teeth); group 3: GPX

(25-mm-long teeth); group 4: GPX and xylol as solvent (25-mm-long teeth); and group 5: hand files and xylol as solvent. The amount of time for gutta-percha removal and the number of fractured instruments were evaluated. Radiographs were taken, and the teeth were grooved longitudinally and split. The area of residual debris was measured using Sigma Scan software.

Results. The time for filling material removal was significantly shorter when GPX was used (P < .05). Overall, hand files and solvent produced fewer remnants of filling materials (P < .05). In the GPX 25 mm-long teeth group, the filling material was not removed in the apical third.

Conclusions. Under the experimental conditions,

the GPX instruments proved to be faster than hand instruments in removing root filling materials; however, hand instruments left a smaller amount of residual filling materials on the canal walls. The GPX instruments did not pull the gutta-percha beyond its tip. (Oral Surg Oral Med Oral Pathol Oral Radiol Selleckchem Stem Cell Compound Library Endod 2010; 110: 675-680)”
“Little is known about the molecular genetic diversity of most Passiflora species. We used RAPD markers to evaluate the genetic diversity of 24 genotypes of the ‘sleep’ passion fruit (Passiflora setacea). Twelve primers generated 95 markers, 88% of which were polymorphic. The genetic distance estimated by the complement of the Dice index ranged from 0.29 (among accessions Ps-G1 and Ps-G13) to 0.69 (among accessions Ps-G21 and Ps-G23). Genotype grouping based on the UPGMA algorithm showed considerable variability among genotypes. We conclude that P. setacea has a broad genetic base that could be exploited in breeding programs.

Clinical decision-making, individualized

patient therapy, communication with patients and between professionals, and application of guidelines were found to be particularly challenging. These issues are discussed in the context of the newly revised Canadian Cardiovascular Society (CCS) AF Guidelines.

Conclusions: selleckchem Educational gaps exist across the entire continuum of care. Results from this study, along with the 2011 CCS guidelines for AF management, provide direction for solutions through physician education and professional development.”
“Background: The mitogen-activated protein kinase (MAPK) signaling pathway is one of the major cascades that are crucial for the initiation and progression of melanoma; however, the influence of these signaling molecules on patient survival has not been clarified.

Objective: The purpose of this study was to analyze the protein expression of MAPK signaling molecules in melanoma, and to correlate the expression status with clinicopathologic parameters.

Methods: Expression of c-Kit, phosphorylated ERK (p-ERK), and cyclin D1 was examined by immunohistochemistry in 78 primary melanomas, 24 metastatic lesions, and in 42 benign nevi. The following clinicopathologic variables were evaluated: age, gender, histologic type, tumor site, Breslow thickness, Clark’s level, ulceration, and survival period. Statistical analyses were performed for assessment of associations and melanoma-specific

survival.

Results: The expression of c-Kit, p-ERK, and cyclin D1 was significantly higher in primary melanomas than in nevi. c-Kit immunoreactivity HSP inhibitor was highest in thin (Tis-pT2) melanomas, and showed a significant reduction with tumor progression and metastasis. The expression of p-ERK was high in all stages of melanoma. Cyclin D1 positivity increased significantly according to tumor progression, but decreased in metastases. A significant correlation

between p-ERK and cyclin D1 expression was observed. Survival analysis failed to detect any trends towards shorter or longer survival among patients expressing either c-Kit, p-ERK or cyclin D1.

Conclusions: The expression of c-Kit, p-ERK, and cyclin D1 might help to differentiate thin melanoma from melanocytic nevus, but it appears to lack prognostic potential. (C) 2011 Japanese Society for Investigative Dermatology. Published by JIB-04 mw Elsevier Ireland Ltd. All rights reserved.”
“Borrelia burgdorferi is a spirochaete that can penetrate the blood-brain barrier in early infection and can cause endothelial damage other than central nervous system lesions. We describe a clinical case of neuroborreliosis that occurred in the absence of classical erythema migrans or arthralgia. Magnetic resonance imaging findings compatible with simil-vasculitis and demyelinating lesions associated with the presence of anti-B. burgdorferi antibodies in the plasma or cerebrospinal liquid is an indication for antimicrobial treatment against B.

gingivalis-accelerated atherosclerosis.”
“A 68-year-old woman was admitted to our hospital because of back pain and syncope. Transthoracic echocardiography revealed pericardial effusion, a collapsed right ventricle, a giant aneurysm connected to the coronary sinus, a dilated left main trunk coronary artery, and a dilated left circumflex artery (LCx). Furthermore, there was a coronary artery fistula arising from the LCx that drained into the coronary sinus. We diagnosed cardiac tamponade due to rupture of the coronary

artery fistula or giant aneurysm, and successful emergency surgery was performed. Rupture of coronary artery aneurysm or coronary artery fistula is very rare. Transthoracic two-dimensional echocardiography was very useful in our case for the diagnosis of cardiac tamponade, giant coronary aneurysm, and coronary artery fistula.”
“Typically, chemopreventive agents involve either PI3K inhibitor induction of phase II detoxifying enzymes and/or inhibition of cytochrome P450 enzymes (CYPs) that are required for the activation of procarcinogens. In this study, we investigated the protective effects of phloretin against aflatoxin B1 (AFB1) activation to the ultimate carcinogenic intermediate, AFB1-8, 9-epoxide (AFBO), and its subsequent detoxification. Phloretin markedly inhibited formation of the epoxide check details with

human liver microsomes in a dose-dependent manner. Phloretin also inhibited the activities of nifedipine oxidation

and ethoxyresorufin O-deethylase (EROD) in human liver microsomes. These data show that phloretin strongly inhibits CYP1A2 and CYP3A4 activities, which are involved in the activation of AFB1. Phloretin increased glutathione S-transferase (GST) activity of alpha mouse liver 12 (AML 12) cells in a dose-dependent manner. GST activity toward AFBO in cell lysates treated with 20 mu M phloretin was 23-fold that of untreated control cell lysates. The expression of GSTA3, GSTA4, GSTM1, GSTP1 and GSTT1 was induced by phloretin in a dose-dependent manner in AML 12 cells. GSTP1, GSTM1, and GSTT1 were able to significantly increase the conjugation of AFBO with glutathione. Concurrently, induction of the GST isozyme genes was partially associated with the Nrf2/ARE pathway. Taken together, the results AF 2838 demonstrate that phloretin has a strong chemopreventive effect against AFB1 through its inhibitory effect on CYP1A2, CYP3A4, and its inductive effect on GST activity.”
“The occasional presence of relatively high amounts of natural estrogens in milk and milk derivatives and the abusive or illegal use of synthetic estrogens in dairy practices have become causes for concern, since intake of these hormones is associated with illnesses or disorders. Development of methodologies that confirm or deny the presence of natural and synthetic estrogens, their metabolites and other compounds with estrogenic activity is very important.

Results: We identified TE events in 11 patients (2.7%) within 7 days after pacemaker implantation. Four of the 11 (36.4%) patients died of complications of TE. Univariate analysis revealed that an age of >75 years (4.56 odds ratio [OR], P = 0.031), hypertension (3.59 OR, P = 0.028), diabetes (8.89 OR, P < 0.001), coronary heart disease (4.8 OR, P = 0.005),

atrial fibrillation (AF) (5.68 OR, P = 0.006), persistent AF (10.36 OR, P < 0.001), and a history of stroke or transient ischemic attack (5.62 OR, P = 0.002) were associated with an increased risk of TE events. Multivariate Vorasidenib chemical structure logistic analysis showed that persistent AF (9.8 OR, P < 0.001) was independently associated with TE. The incidence of perioperative TE was not significantly different between patients with single-and dual-chamber pacemakers.

Conclusions: We found TE events during the perioperative period in patients undergoing pacemaker implantation were not uncommon. Because persistent AF during the perioperative period was the only independent risk factor for perioperative Vactosertib cost TE, appropriate anticoagulation therapy may be necessary in those patients.”
“Aims: The aims of this study were

to determine how we can differentiate detrusor after-contraction (DAC) from artifacts, and to understand the clinical implications and significance of DAC. Materials and Methods: A retrospective analysis was performed on 2,309 patients with neurogenic or non-neurogenic voiding dysfunction. Investigators asked patients to cough when detrusor contraction occurred following cessation of urinary flow. No simultaneous change of detrusor pressure (P(det)) could Selleckchem Tozasertib confirm that P(det) increase could be regarded as true DAC. Patients were subcategorized according to the presence of large postvoid urine volume, increase of electromyographic activity, the amount

of P(det) change, and multiplicity. Results: Detrusor contraction occurred after cessation of urinary flow in 245 patients (10.6%). The contractions of 57 patients (23.3%) were regarded as artifacts. DAC was identified in 188 patients (132 males, 5.7% and 56 females, 2.4%). The mean increase in P(det) from the initiation of DAC to the maximal P(det) of DAC was 22.6 +/- 11.2 cmH(2)O in males, and 18.6 +/- 7.9 cmH(2)O in females. DAC occurred more frequently as males became older. Detrusor pressures at maximal flow were higher in patients with DAC. Patients of both genders with bladder outlet obstruction (BOO) had an increased risk of developing DAC. Males with benign prostatic hyperplasia had an increased risk of developing DAC. Conclusions: DAC should be differentiated from artifacts using cough test and the presence of DAC was significantly correlated to the presence of BOO. Neurourol. Urodynam. 30:1361-1365, 2011. (C) 2011 Wiley-Liss, Inc.”
“Background: Improvements in trauma systems and resuscitation have increased survival in severely injured patients.

Because the human lens grows throughout life, the lens core is exposed for a longer period to such influences and the risk of oxidative damage increases in the fourth decade when a barrier to the transport of glutathione forms

around the lens nucleus. Consequently, as the lens ages, its transparency falls and the nucleus becomes more rigid, resisting the change in shape necessary for accommodation. This is the basis of presbyopia. In some individuals, the steady accumulation of chromophores and complex, insoluble crystallin aggregates in the lens nucleus leads to the formation of a brown nuclear cataract. The process is homogeneous and the affected lens fibres retain their gross morphology. Cortical opacities are due to changes in membrane permeability and enzyme function and shear-stress damage to lens fibres with continued accommodative effort. Unlike nuclear cataract, PX-478 research buy progression is intermittent, stepwise and non-uniform.”
“BACKGROUND: Little is known about primary care professionals’ concerns about risks to patient safety.

AIM: To identify threats to patient safety in the primary care office from the perspective of physicians

and nurses.

DESIGN: Cross-sectional survey; participants were asked to name and rank threats to safety they personally were most concerned about.

SETTING: Physicians and nurses working in primary care offices in Switzerland.

METHODS: Verbatim reports were analysed under an inductive content-analysis framework. Coded threats were quantitatively analysed in terms of frequency PD-1/PD-L1 Inhibitor 3 purchase and prioritisation. Differences between physicians and nurses were analysed.

RESULTS: Of 1260 invited individuals, 630 responded to the survey and 391 (31%) described 936 threats to patient safety. The coding system included 29 see more categories organised in 5 themes. Agreement of coders was good (kappa = 0.87, CI = 0.86-0.87). Safety of medication (8.8%), triage by nurses (7.2%) and drug interactions (6.8%) were the threats cited most frequently. Errors in diagnosis (OR = 0.21, CI 0.09-0.47, p <0.001), drug interactions (OR

= 0.10, CI 0.04-0.25, p <0.001) and compliance of patients (OR = 0.28, CI 0.08-0.96, p = 0.044) were more likely to be cited by physicians. X-rays (OR = 3.34, CI 1.04-10.71, p = 0.043), confusion of patients or records (OR = 3.28, CI 1.55-6.94, p = 0.002), hygiene (OR = 3.21, CI 1.12-9.19, p = 0.030), safety of office rooms (OR = 6.70, CI 1.46-30.73, p = 0.014), and confidentiality (OR = 7.38, CI 1.63-33.50, p = 0.010) were more likely to be described by nurses.

CONCLUSION: Physicians and nurses are concerned about diverse threats to patient safety in primary care. Involving both groups in detection and analysis of risks in medical offices seems a valuable strategy to improve collaboration and safety.